Roth's Spots:

Roth's spots are retinal hemorrhages with white or pale centers composed of coagulated fibrin.

They are usually caused by immune complex mediated vasculitis often resulting from bacterial endocarditis.

Roth's spots are named after Moritz Roth.

These "white-centered" hemorrhages originally described in patients with bacterial endocarditis, are not specific for that disease.

They probably reflect microinfarcts, just like cotton wool spots, and occur in a litany of disorders, including essential hypertension, Leukemia, diabetes,ischemic events, pernicious anaemia , HIV, connective tissue disease Behçet's disease, viremia, and hypercoagulable states.

While Roth spots are not specific for endocarditis, discovering them in a patient who has other suggestive features of endocarditis constitutes strong support for the diagnosis.

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