RODENT OR MOOREN’S ULCER

Mooren's ulcer is a rare, non-healing ulceration of the cornea, typically found in the inferonasal quadrant. It is named after the German ophthalmologist, Paul Mooren. The cause of Mooren's ulcer is not entirely understood, but it is thought to be an immune-mediated disorder.

Symptoms: -Pain, redness, and decreased vision in the affected eye -Ulceration of the cornea

Risk Factors: -Immune system disorders, such as rheumatoid arthritis and sarcoidosis -Certain genetic conditions, such as Cogan's syndrome and Herpes zoster ophthalmicus

Diagnosis: -An eye examination with a slit-lamp, which allows the doctor to examine the front part of the eye in great detail. -A keratoplasty (corneal transplant) may be necessary to remove the ulcerated tissue and replace it with healthy tissue from a donor cornea.

Treatment: -Immunosuppressive therapy, such as prednisone, azathioprine, cyclosporine, or mycophenolate mofetil, is the mainstay of treatment for Mooren's ulcer. -Topical therapy with antiviral, antibacterial, and/or antifungal agents may be used to prevent or treat secondary infections. -In case of cornea perforation or deep ulcer, a corneal transplant may be necessary to save the eye.

Prognosis: -The prognosis for Mooren's ulcer is generally poor, with a high risk of corneal perforation and loss of vision. -Frequent follow-up and monitoring by an eye care professional is important to detect and treat any complications as soon as possible.

In summary, Mooren's ulcer is a rare but severe corneal disorder with an uncertain etiology, usually presenting as a painful, non-healing ulcer in inferonasal quadrant of cornea and associated with underlying systemic disorders like sarcoidosis, RA. Timely diagnosis and management with immunosuppressant therapy, along with appropriate topical treatment can help prevent corneal perforation and blindness. However, in cases of cornea perforation or deep ulcer, a corneal transplant may be necessary to save the eye.

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